The following is quoted from the email/article:
A new meta-analysis provides more evidence that taller people may be more likely than their shorter peers to develop colorectal cancer (CRC) or colon polyps.
"There are well-known modifiable dietary associations for colorectal cancer, such as processed red meats and smoking, but guidelines currently are fixated on family history, and height is clinically neglected when it comes to risk screening," study investigator Gerard Mullin, MD, with Johns Hopkins University School of Medicine, Baltimore, Maryland, says in a news release. This large study "builds on evidence that taller height is an overlooked risk factor and should be considered when evaluating and recommending patients for colorectal cancer screenings."
The study was published online March 1 in Cancer Epidemiology, Biomarkers & Prevention. According to co-first author Elinor Zhou, MD, also with Johns Hopkins University School of Medicine, Baltimore, Maryland, a potential explanation for this link "is that adult height correlates with body organ size. More active proliferation in organs of taller people could increase the possibility of mutations leading to malignant transformation."
The researchers say that more research is needed to identify particular subgroups of tall people at risk for CRC.
Comments (author identified here only by initial) on Medscape on the article, 5 in all:
First comment on article: by Dr. W:
Of course height is correlated with cancer. Cancer cells are loaded with IGF-1 [insulin-like growth factor] receptors. And people with a lot of IGF-1, either because they make a lot of it on their own, or because they drink a lot of cows' milk, are going to be taller. People that don't make IGF-1, are dwarfs -- but they don't get cancer.
Second comment on article: by Dr. M:
I can't comment on the specific relation of height and CRC, but height is positively correlated to all-cause mortality.
Comment on Dr. W's comment, by Dr. C:
they don't get cancer at all ? i find that rather unlikely...
Comment on Dr. C's comment, by Dr. W:
A paper by Steuerman, Shevah, and Laron has: "performed a worldwide survey and collected data on 538 patients." And "none of the 230 Laron Syndrome (the dwarfs) patients had cancer."
Zvi Laron has his email on the paper, but its not clear enough on my screen.
Comment on Dr. W's latest by B.G.:
Dwarfs are also less likely to get diabetes.
End of Medscape comments (all early on March 20, 2022). No more comments as of last check: May 31, 2022.
Regardless of whether cancer is caused by mutations or aneuploidy, the critical issue with "getting cancer" is whether the body can successfully rid itself of cancerous cells that may exist. The body's effort may not be enough, if the cancer cells are provided with enough IGF-1.
IGF-1 is absent from plant sources of food. The correct way to allow the body to rid itself of cancer cells is identified in the title of the book by Dr. John Kelly: Stop Feeding Your Cancer.Return to text.