Clinical Practice Guidelines are established by committees of experts, some of whom receive money from drug companies. Doctors publishing, in the medical literature, results on a drug's effectiveness are supposed to report receiving money from the drug company. It has been noted, however, that when the companies' own records, needed for tax purposes, are investigated, they sometimes show payments to doctors that are not reported by these doctors in the literature.

Since following the guidelines is the safe way to avoid a successful lawsuit, drug companies have some leverage over doctors.

Doctors should be wary about rationalizing the Clinical Practice Guidelines to themselves.
They should go nowhere near rationalizing these to their patients.